Windows key+D: This shortcut is the keyboard equivalent of “Show the Desktop”. It is useful for quickly minimizing every open window when someone walks in and you are doing some private work.
Ctrl+Shift+Esc: This shortcut directly starts the task manager. While Alt+Ctrl+Del was used to bring out the Task Manager in Windows XP and earlier versions, in Windows 10, Windows 8.1, Windows 8 and Windows 7, it just brings up the lock this computer screen.
Ctrl+Click: This shortcut is useful for opening a link in a background tab. This is useful when you have to load a page without leaving the current one.
Alt+Print Screen: takes the screenshot of the current active window as opposed to just Print Screen which takes the screenshot of the entire screen.
Shift+Click for Yes to All and No to All: If you have a lot of dialog boxes asking yes and no question, just shift+click Yes or No on one to yes all or no all.
Ctrl+C on an error dialog box to copy its contents: Suppose your computer is giving an error message and you want to copy its contents to send to the support guy, what do you do? Just press Ctrl+C while the dialog box is highlighted and its contents will be copied to your clipboard.
Ctrl+T: This keyboard shortcut opens a new tab in internet browsers.
Ctrl+Shift+T: Reopens the last closed tab.
Ctrl+Shift+N: This shortcut opens a new incognito window in Google Chrome.
Ctrl+Shift+P: Opens a new private window in Mozilla Firefox.
Alt+Enter after writing the domain name in the address bar of your browser to insert .com automatically.
Shift+Enter inserts .net domain name extension.
Ctrl+W: This shortcut closes the current tab in your browser quickly.
Ctrl+Backspace: This shortcut deletes the last word you have typed. It is useful in case you typed in a wrong word and want to delete it quickly.
Ctrl+Left or Right Arrow key: This shortcut allows you to move the cursor one word at a time instead of the default one character at a time.
Ctrl++: This shortcut allows you to zoom in web pages in web browsers. Useful when text on a web page is too small to read properly. Ctrl+Scroll wheel can also zoom in documents, file thumbnails and icons in Windows 10, Windows 8.1, Windows 8, Windows 7 and Windows Vista.
Ctrl+-: This shortcut does the reverse of the previous shortcut.
Ctrl+0: Reset the webpage's zoom.
Windows key+M: Minimizes all the open windows.
Ctrl+L: This shortcut allows you to quickly jump to the address bar of your web browser.
Windows key+Pause/Break: Quickly open the system properties dialog box.
Ctrl+Shift+Delete: This shortcut opens the option to delete your browser's history, cookies, cache and other details that it stores while you browse the internet. This shortcut is extremely useful for the privacy conscious.
Windows Key+L: This shortcut locks your computer.
Ctrl+H: makes the history appear.
CTRL+B: Bold CTRL+U: Underline CTRL+I: Italic.
Alt+Select: This shortcut allows you to select rectangular blocks of text in Word processors, something that is not possible with simple select.
F2: Allows you to rename the selected file.
Holding Shift while inserting a device with removable storage prevents automatic run.
Ctrl+F: This keyboard shortcut opens the Find option in any program.
Ctrl+S: If you are working on a software and want to quickly save your progress, this shortcut will come in handy.
Ctrl+Home and Ctrl+End: Useful for quickly going to the top and bottom of a page.
Ctrl+P: Useful for printing the current page.
Space Bar: While viewing a web page in a browser, pressing space bar moves the page down.
Alt+Tab: Useful for quickly cycling between running applications. Press along with Shift to cycle backwards.
Ctrl+Tab: Cycle between tabs in your browser.
Ctrl+F5: Clears the cache and refreshes the current tab.
Shift+Right click: Open alternate right click options.
Alt+Double click: Open the file's properties. Alt+Enter can also be used for this.
These are some keyboard shortcuts that I found extremely useful. If you know some more useful keyboard shortcuts, do mention them in the comments.